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ABSTRACT
Ponstane Fort, a famous pharmaceutical drug has many medicinal uses. Recently, it has been used in different chemical reactions in order to improve its biological effectiveness. Three chemical compounds have been prepared as derivatives of Mefenamic acid by certain steps included adding thio semicarbazide to Mefenamic acid with a catalyst of H2SO4 to obtain a Mefenamic derivative Cl; mixing a certain amount of Cl with 4-carboxybenzaldehyde to obtain compound C2; dissolving C2 at various reagents by diazotization reaction to yield Mefenamic derivative C3. All formatted compounds had been monitored through FTIR-Spectra, 'H.NMR-Spectra, Mass-Spectra and melting point. This method has high target product productivity, simple process procedures, mild reaction conditions, simple purifying process, high product purity and suitability for industrialized production. So that the production cost is further reduced. By using the agar well diffusion method, all prepared three compounds showed good antibacterial activity against studied Gram-positive and Gram-negative bacteria, however, C3 showed the highest activity. A skin test for Delayed Hypersensitivity was done to know if there are allergic reactions for the created compounds, while the test for Killing Mice has been done for testing mortality rate in animals. The compounds have a high cellular immune response through in experimental animals.
Keywords: Mefenamic acid, Thiadiazole, Schiff base, Hypersensitivity, Antibacterial activity, Heterocyclic rings, Azo compounds.
INTRODUCTION
A cyclic compound with two different atoms, at least, as members of its ring is known as a heterocyclic compound. Heterocyclic chemistry is the area of organic chemistry that deals with synthesis, characteristics, and uses of heterocyclic. The bulk pharmaceuticals, most biomass (cellulose and related materials), all nucleic acids, and several natural and manmade colours are heterocyclic compounds. In addition, heterocyclic compound having interesting anticancer capabilities, also playing a key role in the development of anticancer medications (Sabah et al. 2020; Ayoub et al. 2021; Aljeboree et al. 2023; Sabah et al. 2023; Al-Shik et al. 2023). In relation to a variety of settings, including antibacterial, antiviral, and anticancer activities, Schiff bases have been studied (Cimolai 2013; Zamil et al. 2020). They have also been taken into consideration to prevent the aggregation of amyloid. When an amine, such as the terminal group of a lysine residue, reversibly interacts with an aldehyde or ketone of a cofactor or substrate,...