Abstract

Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and reactive oxygen species (ROS) metabolism, including the XC−/GSH/GPX4 system, ACSL4/LPCAT3/15-LOX and FSP1/CoQ10/NAD(P)H pathways, and investigate the correlation between ferroptosis and LncRNA in BC to determine possible biomarkers related to ferroptosis.

Details

Title
Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Author
Xiang, Shasha 1 ; Yan, Wen 2 ; Ren, Xing 3 ; Feng, Jianbo 2   VIAFID ORCID Logo  ; Zu, Xuyu 2 

1  University of South China, Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, Hengyang, China (GRID:grid.412017.1) (ISNI:0000 0001 0266 8918); University of South China, Department of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, Hengyang, China (GRID:grid.412017.1) (ISNI:0000 0001 0266 8918) 
2  University of South China, Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, Hengyang, China (GRID:grid.412017.1) (ISNI:0000 0001 0266 8918) 
3  University of South China, Department of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, Hengyang, China (GRID:grid.412017.1) (ISNI:0000 0001 0266 8918) 
Pages
40
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
ISSN
1425-8153
e-ISSN
1689-1392
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s11658-024-00560-2
ProQuest document ID
2984912126
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.