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This study aimed to evaluate the antimicrobial properties, cell viability, and matrix metalloproteinase (MMP) inhibition capacity of several endodontic materials aimed at vital pulp therapy: Pro Root MTA®, EndoSequence®, Biodentine®, MTA Angelus®, TheraCal LC®, and BioC Repair®. The materials were prepared according to the manufacturer’s instructions. Antimicrobial tests were conducted using a microcosm biofilm model, cell viability was assessed using murine fibroblasts (L929), and MMP activity was analyzed through electrophoresis. The results showed that BioC Repair®, Biodentine®, and EndoSequence® exhibited similar antimicrobial properties, while MTA Angelus® and ProRoot MTA® had inferior results but were comparable to each other. In terms of cell viability, no significant differences were observed among the materials. EndoSequence® demonstrated the highest MMP inhibition capacity. In conclusion, BioC Repair®, Biodentine®, EndoSequence®, and TheraCal® showed better antimicrobial properties among the tested materials. The materials did not exhibit significant differences in terms of cytotoxicity. However, EndoSequence® displayed superior MMP inhibition capacity.
Details
; Adriana Fernandes da Silva 1
; Wellington Luiz de Oliveira da Rosa 1 ; Borges, Álvaro Henrique 2 ; Neftali Lenin Villarreal Carreno 4
; Piva, Evandro 5
; Rafael Guerra Lund 5
1 Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas (UFPEL), Pelotas 96015-560, Brazil;
2 Graduate Program in Dentistry, School of Dentistry, University of Cuiabá (UNIC), Cuiabá 78000-000, Brazil;
3 Graduate Program in Dentistry, School on Dentistry, Autonomous University of State of Hidalgo, San Agustín Tlaxiaca, Pachuca de Soto 42080, Mexico;
4 Graduate Program in Materials Science and Engineering, Technological Development Center, Federal University of Pelotas (UFPEL), Pelotas 96010-610, Brazil;
5 Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas (UFPEL), Pelotas 96015-560, Brazil;