Abstract

Background

Colorectal cancer (CRC) ranks third in cancer incidence globally and is the second leading cause of cancer-related mortality. The nucleoside diphosphate kinase 1 (NME1) and netrin 1 receptor (DCC) genes have been associated with resistance against tumorigenesis and tumor metastasis. This study investigates the potential association between NME1 (rs34214448 G > T and rs2302254 C > T) and DCC (rs2229080 G > C and rs714 A > G) variants and susceptibility to colorectal cancer development.

Methods

Samples from 232 colorectal cancer patients and 232 healthy blood donors underwent analysis. Variants were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) methodology. Associations were assessed using odds ratios (OR), and the p values were adjusted with Bonferroni test.

Results

Individuals carrying the G/T and T/T genotypes for the NME1 rs34214448 variant exhibited a higher susceptibility for develop colorectal cancer (OR = 2.68, 95% CI: 1.76–4.09, P = 0.001 and OR = 2.47, 95% CI: 1.37–4.47, P = 0.001, respectively). These genotypes showed significant associations in patients over 50 years (OR = 2.87, 95% CI: 1.81–4.54, P = 0.001 and OR = 2.99, 95% CI: 1.54–5.79, P = 0.001 respectively) and with early Tumor-Nodule-Metastasis (TNM) stage (P = 0.001), and tumor location in the rectum (P = 0.001). Furthermore, the DCC rs2229080 variant revealed that carriers of the G/C genotype had an increased risk for develop colorectal cancer (OR = 2.00, 95% CI: 1.28–3.11, P = 0.002) and were associated with age over 50 years, sex, and advanced TNM stages (P = 0.001).

Conclusions

These findings suggest that the NME1 rs34214448 and DCC rs2229080 variants play a significant role in colorectal cancer development.

Details

Title
NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer
Author
Márquez-González, Rosa María 1 ; Saucedo-Sariñana, Anilú Margarita 1 ; de Jesús Tovar-Jacome, César 1 ; Barros-Núñez, Patricio 2 ; Gallegos-Arreola, Martha Patricia 3 ; Orozco-Gutiérrez, Mario Humberto 1 ; Mariscal-Ramírez, Ignacio 4 ; Pineda-Razo, Tomas Daniel 4 ; Alcaraz-Wong, Aldo Antonio 5 ; Marín-Contreras, María Eugenia 6 ; Rosales-Reynoso, Mónica Alejandra 1   VIAFID ORCID Logo 

1  Instituto Mexicano del Seguro Social (IMSS), Colonia Independencia Guadalajara, División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Jalisco, México (GRID:grid.419157.f) (ISNI:0000 0001 1091 9430) 
2  Centro Universitario de Ciencias de La Salud. Universidad de Guadalajara, Doctorado en Genética Humana, Jalisco, México (GRID:grid.412890.6) (ISNI:0000 0001 2158 0196) 
3  Instituto Mexicano del Seguro Social (IMSS), División de Genética, Centro de Investigación Biomédica de Occidente, Guadalajara, México (GRID:grid.419157.f) (ISNI:0000 0001 1091 9430) 
4  Instituto Mexicano del Seguro Social (IMSS), Servicio de Oncología Médica, Hospital de Especialidades, Guadalajara, México (GRID:grid.419157.f) (ISNI:0000 0001 1091 9430) 
5  Instituto Mexicano del Seguro Social (IMSS), Servicio de Anatomía Patológica, Hospital de Especialidades, Guadalajara, México (GRID:grid.419157.f) (ISNI:0000 0001 1091 9430) 
6  Instituto Mexicano del Seguro Social (IMSS), Servicio de Gastroenterología, Hospital de Especialidades, Guadalajara, México (GRID:grid.419157.f) (ISNI:0000 0001 1091 9430) 
Pages
10
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
ISSN
11100362
e-ISSN
25890409
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s43046-024-00213-7
ProQuest document ID
3020637247
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.