It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Chronic musculoskeletal pain including knee osteoarthritis (OA) is a leading cause of disability worldwide. Previous research indicates ethnic-race groups differ in the pain and functional limitations experienced with knee OA. However, when socioenvironmental factors are included in analyses, group differences in pain and function wane. Pain-related brain structures are another area where ethnic-race group differences have been observed. Environmental and sociocultural factors e.g., income, education, experiences of discrimination, and social support influence brain structures. We investigate if environmental and sociocultural factors reduce previously observed ethnic-race group differences in pain-related brain structures. Data were analyzed from 147 self-identified non-Hispanic black (NHB) and non-Hispanic white (NHW), middle and older aged adults with knee pain in the past month. Information collected included health and pain history, environmental and sociocultural resources, and brain imaging. The NHB adults were younger and reported lower income and education compared to their NHW peers. In hierarchical multiple regression models, sociocultural and environmental factors explained 6–37% of the variance in pain-related brain regions. Self-identified ethnicity-race provided an additional 4–13% of explanatory value in the amygdala, hippocampus, insula, bilateral primary somatosensory cortex, and thalamus. In the rostral/caudal anterior cingulate and dorsolateral prefrontal cortex, self-identified ethnicity-race was not a predictor after accounting for environmental, sociocultural, and demographic factors. Findings help to disentangle and identify some of the factors contributing to ethnic-race group disparities in pain-related brain structures. Numerous arrays of environmental and sociocultural factors remain to be investigated. Further, the differing sociodemographic representation of our NHB and NHW participants highlights the role for intersectional considerations in future research.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 University of Florida, Department of Biobehavioral Nursing Science, College of Nursing, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
2 University of Florida, Department of Clinical and Health Psychology, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
3 University of Florida, Pain Research and Intervention Center of Excellence, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091); University of Florida, Department of Physical Medicine and Rehabilitation, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
4 University of Florida, Department of Biobehavioral Nursing Science, College of Nursing, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091); University of Florida, Pain Research and Intervention Center of Excellence, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
5 University of Florida, Department of Anesthesiology, Division of Pain Medicine, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
6 University of Florida, Department of Radiation Oncology, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
7 University of Alabama at Birmingham, Department of Radiology, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000 0001 0634 4187)
8 University of Florida, Department of Rheumatology, College of Medicine, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
9 University of Alabama at Birmingham, Department of Biostatistics, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000 0001 0634 4187)
10 University of Alabama at Birmingham, Department of Psychology, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000 0001 0634 4187); Washington University, Department of Anesthesiology, St. Louis, USA (GRID:grid.34477.33) (ISNI:0000 0001 2298 6657)
11 University of Florida College of Dentistry, Department of Community Dentistry and Behavioral Science, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091); University of Florida, Pain Research and Intervention Center of Excellence, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)
12 University of Florida, Department of Physical Medicine and Rehabilitation, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091); University of Florida, Department of Anesthesiology, Division of Pain Medicine, Gainesville, USA (GRID:grid.15276.37) (ISNI:0000 0004 1936 8091)