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Abstract
Ankylosing spondylitis (AS) is the historic term used for decades for the HLA-B27-associated inflammatory disease affecting mainly the sacroiliac joints (SIJ) and spine. Classification criteria for AS have radiographic sacroiliitis as a dominant characteristic. However, with the availability of MRI of SIJ, it could be demonstrated that the disease starts long before definite SIJ changes become visible on radiographs. The Assessment of SpondyloArthritis international Society, representing a worldwide group of experts reached consensus on changes in the nomenclature pertaining to axial spondyloarthritis (axSpA), such as the terminology of diagnosis and of assessment of disease activity tools. These are important changes in the field, as experts in axSpA are now in agreement that the term axSpA is the overall term for the disease. A further differentiation, of which radiographic versus non-radiographic is only one aspect, may be relevant for research purposes. Another important decision was that the terms AS and radiographic axSpA (r-axSpA) can be used interchangeably, but that the preferred term is r-axSpA. Based on the decision that axSpA is the correct terminology, a proposal was made to officially change the meaning of the ASDAS acronym to ‘Axial Spondyloarthritis Disease Activity Score’. In addition, for simplification it was proposed that the term ASDAS (instead of ASDAS-CRP) should be preferred and applied to the ASDAS calculated with C reactive protein (CRP). It is hoped that these changes will be used consequently for education, in textbooks, manuscripts and presentations.
Details
; Molto, Anna 2
; Sofia Ramiro 3
; Braun, Jürgen 4
; Dougados, Maxime 5
; van Gaalen, Floris A 1
; Gensler, Lianne S 6
; Inman, Robert D 7
; Landewé, Robert B M 8
; Marzo-Ortega, Helena 9
; Navarro-Compán, Victoria 10
; Phoka, Andri 11 ; Poddubnyy, Denis 12
; Protopopov, Mikhail 12
; Reveille, John 13
; Rudwaleit, Martin 14
; Sampaio-Barros, Percival 15 ; Sepriano, Alexandre 16
; Sieper, Joachim 12
; Filip E Van den Bosch 17
; van der Horst-Bruinsma, Irene 18 ; Machado, Pedro M 19 ; Baraliakos, Xenofon 4
1 Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
2 Rheumatology, Hospital Cochin, Paris, France; Université Paris-Cité, INSERM U1153, Paris, France
3 Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Rheumatology, Zuyderland Medical Centre, Heerlen, The Netherlands
4 Rheumazentrum Ruhrgebiet, Ruhr University Bochum, Herne, Germany
5 Hopital Cochin, Rheumatology, Université Paris Descartes Faculté de Médecine, Paris, France
6 Medicine/Rheumatology, University of California, San Francisco, California, USA
7 Schroeder Arthritis Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
8 Rheumatology, Zuyderland Medical Centre, Heerlen, The Netherlands; Rheumatology, Amsterdam University Medical Center, Amsterdam, The Netherlands
9 NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK
10 Rheumatology, University Hospital La Paz, IdiPaz, Madrid, Spain
11 ASIF, London, UK
12 Gastroenterology, Infectious Diseases and Rheumatology (including Nutrition Medicine), Charité Universitätsmedizin Berlin, Berlin, Germany
13 Rheumatology, University of Texas McGovern Medical School, Houston, Texas, USA
14 Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany
15 Rheumatology, Faculdade de Medicina da Universidade de São Paulo e Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
16 Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Nova Medical School, Universidade Nova de Lisboa, Lisboa, Portugal
17 Rheumatology, Ghent University Hospital, Gent, Belgium; Internal Medicine and Pediatrics, VIB-UGent Center for Inflammation Research, Ghent University, Gent, Belgium
18 Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
19 Rheumatology and Neuromuscular Diseases, University College London, National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, London, UK; NHS Foundation Trust, London, UK; Rheumatology, Norhwick Park Hospital, London North West University Healthcare NHS Trust, London, UK