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Human immunodeficiency virus (HIV) is a significant global health issue that affects a substantial number of individuals across the globe, with a total of 39 million individuals living with HIV/AIDS. ART has resulted in a reduction in HIV-related mortality. Nevertheless, the issue of medication resistance is a significant obstacle in the management of HIV/AIDS. The unique genetic composition of HIV enables it to undergo rapid mutations and adapt, leading to the emergence of drug-resistant forms. The development of drug resistance can be attributed to various circumstances, including noncompliance with treatment regimens, insufficient dosage, interactions between drugs, viral mutations, preexposure prophylactics, and transmission from mother to child. It is therefore essential to comprehend the molecular components of HIV and the mechanisms of antiretroviral medications to devise efficacious treatment options for HIV/AIDS.
Details
Drug interaction;
Human immunodeficiency virus--HIV;
Disease resistance;
Public health;
Medical prognosis;
Mortality;
Immune system;
Drug resistance;
Genetic engineering;
Viruses;
Genomes;
Acquired immune deficiency syndrome--AIDS;
Antiretroviral agents;
Genes;
Apoptosis;
Enzymes;
Mutation;
Cell cycle;
Proteins;
Drug therapy;
Antiretroviral therapy
; Dinu-Pîrvu, Cristina Elena 1 ; Drăgănescu, Doina 1 ; Fâcă, Anca Ionela 2 ; Udeanu, Denisa Ioana 2
; Arsene, Andreea Letiția 2
1 Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania;
2 Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania;