Choix de l'activite de source du palladium-103 afin d'optimiser la qualite d'un implant permanent de la prostate

Abstract

Pour les implants permanents de la prostate au ¹⁰³Pd, nous avons étudié l'effet de la migration des sources radioactives sur la couverture en dose (en pourcentage) de la zone cible (la prostate). Pour différents volumes et formes de prostates, nous avons d'abord construit des plans de traitement optimisés et à partir de ceux-ci, nous avons simulé la migration des sources à l'aide d'un programme réaliste de simulations Monte Carlo. Notons que la chute de la couverture en dose après simulation de la migration est dépendante surtout de l'interaction entre l'activité de source utilisée et de l'énergie des gammas émis par le ¹⁰³Pd. Cette baisse de la couverture en dose est maximale pour des activités intermédiaires de 1.35–1.40 mCi et minimale pour des activités faibles de 1.00 mCi. Il est avantageux d'utiliser des sources de 1.00 mCi car les plans sont robustes à la migration, en plus de préserver les organes à risque.

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For permanent 103Pd prostate implants, we studied the effect of migration of radioactive sources on the dose coverage (in percentage) of the target area (the prostate). For different volumes and shapes of prostates, we first constructed optimized treatment plans and from these we simulated source migration using a realistic Monte Carlo simulations program. Note that the drop in dose coverage after simulation of the migration is mainly dependent on the interaction between the source activity used and the energy of the gammas emitted by the 103Pd. This drop in dose coverage is maximum for intermediate activities of 1.35–1.40 mCi and minimum for low activities of 1.00 mCi. It is advantageous to use 1.00 mCi sources because the plans are robust to migration, in addition to preserving organs at risk.