Contributions à Ballista: Minima locaux, fonction de coût avec gradients de dose et optimisation multiobjectifs

Abstract

Le but de la planification de traitement en radiothérapie est d'irradier un volume tumoral à une certaine dose tout en épargnant le mieux possible les organes à risque proches de la tumeur. Un logiciel a été développé à l'Hôtel-Dieu de Québec (HDQ) afin d'optimiser les plans de traitement. Ce logiciel, appelé Ballista, fournit des plans supérieurs à ce qu'un humain peut produire face à un cas complexe. Ballista ne parvient cependant pas à égaler la qualité des plans qu'une planification en technique d'IMRT (la technique la plus avancée disponible à l'HDQ, mais aussi la plus lourde). Ce projet de maîtrise visait justement à travailler au développement de Ballista afin d'améliorer la qualité des plans que ce dernier produit. (Abstract shortened by UMI.)

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The goal of radiotherapy treatment planning is to irradiate a tumor volume at a certain dose while sparing as much as possible the organs at risk close to the tumor. Software was developed at the Hôtel-Dieu de Québec (HDQ) to optimize treatment plans. This software, called Ballista, provides plans superior to what a human can produce when faced with a complex case. Ballista, however, cannot match the quality of the plans than planning using the IMRT technique (the most advanced technique available at HDQ, but also the heaviest). This master's project aimed precisely to work on the development of Ballista in order to improve the quality of the plans that it produces. (Abstract shortened by UMI.)