Content area

Abstract

The pharmaceutical industry has four basic operations to produce tablets: mixing, drying, milling, and tablet pressing. Fluidized bed drying of the pharmaceutical powders is one of the most efficient methods, which is finding ever-growing applications in diverse industries, especially in the pharmaceutical and the food industries. However, one of the problems that exist in the pharmaceutical industry is to determine when the formulation reaches the desired moisture content. This final value can be either determined with a Loss on Drying (LOD) technique on estimated using a model of the process. To obtain this model, it is necessary to know the parameters that control drying process as well as the characteristics of the granulation used in this stage. Unfortunately the modeling of drying is still uncertain. The objective of this research was to determine an empirical correlation for the mass transfer coefficient (kga) of pharmaceutical powders in a Fluid Bed Dryer (FBD) which will then be used a long with fundamental models to predict moisture content. (Abstract shortened by UMI.)

Details

1010268
Identifier / keyword
Title
Determination of an empirical correlation for the mass transfer coefficients of pharmaceutical powders in a fluid bed dryer
Number of pages
99
Degree date
2004
School code
0553
Source
MAI 43/01M, Masters Abstracts International
ISBN
978-0-496-26556-5
University/institution
University of Puerto Rico, Mayaguez (Puerto Rico)
University location
United States -- Puerto Rico
Degree
M.S.
Source type
Dissertation or Thesis
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
1421811
ProQuest document ID
305076676
Document URL
https://www.proquest.com/dissertations-theses/determination-empirical-correlation-mass-transfer/docview/305076676/se-2?accountid=208611
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Database
ProQuest One Academic