Etude des voies d'activation des tyrosine kinases dans le neutrophile humain

Abstract

Le neutrophile est une des premières cellules à parvenir au site inflammatoire. Plusieurs des réponses fonctionnelles de ces cellules font appel à des mécanismes complexes de régulation impliquant les tyrosine kinases. L'objectif de cette étude était d'identifier les tyrosine kinases participant à la signalisation intracellulaire des neutrophiles stimulés par des peptides bactériens formylés comme le fMet-Leu-Phe, par des cristaux d'urate monosodique monohydrate ou suite au pontage du FcγRIIA par des anticorps spécifiques. L'ensemble des résultats obtenus permet de relier l'activité de certaines classes de tyrosines kinase à l'activation de certains types de récepteurs et de confirmer l'importance des tyrosines kinase dans le déclenchement et la régulation de plusieurs fonctions du neutrophile.

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The neutrophil is one of the first cells to reach the inflammatory site. Several of the functional responses of these cells involve complex regulatory mechanisms involving tyrosine kinases. The objective of this study was to identify the tyrosine kinases participating in the intracellular signaling of neutrophils stimulated by formylated bacterial peptides such as fMet-Leu-Phe, by monosodium urate monohydrate crystals or following the bridging of FcγRIIA by specific antibodies. All the results obtained make it possible to link the activity of certain classes of tyrosine kinases to the activation of certain types of receptors and to confirm the importance of tyrosine kinases in the triggering and regulation of several neutrophil functions.