Radiothérapie externe du sein: Amélioration de l'uniformité de la dose au volume cible

Abstract

En radiothérapie externe, le traitement du cancer du sein représente 25% des cas et le sein est un site à l'intérieur duquel la dose délivrée est trop souvent inhomogène. La simulation conventionnelle et la planification bidimensionnelle sont les principales causes de l'inhomogénéité de la dose dans le volume cible, qui se situe entre 90% et 120% de la dose prescrite. Grâce à une nouvelle méthode, la simulation virtuelle, la dose délivrée dans le sein est souvent située entre 95% et 107% de la prescription, soit l'intervalle d'uniformité jugé acceptable pour tous les sites de radiothérapie. L'approche privilégiée est de faire une modulation simple de l'intensité des faisceaux d'irradiation en leur ajoutant des sous-champs lors de la planification désormais basée sur l'anatomie tridimensionnelle. Au niveau médical, une meilleure uniformité de la dose (diminution des surdosages) s'est traduite par une diminution des réactions cutanées par rapport au traitement standard puis à l'implantation en clinique de la nouvelle méthode.

Alternate abstract:

You are viewing a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer

Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer

In external radiotherapy, the treatment of breast cancer represents 25% of cases and the breast is a site within which the dose delivered is too often inhomogeneous. Conventional simulation and two-dimensional planning are the main causes of dose inhomogeneity in the target volume, which is between 90% and 120% of the prescribed dose. Thanks to a new method, virtual simulation, the dose delivered to the breast is often between 95% and 107% of the prescription, i.e. the uniformity interval considered acceptable for all radiotherapy sites. The preferred approach is to make a simple modulation of the intensity of the irradiation beams by adding subfields during planning now based on three-dimensional anatomy. At the medical level, better dose uniformity (reduction in overdoses) resulted in a reduction in skin reactions compared to standard treatment and then to the clinical implementation of the new method.