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Abstract
We probed the associations of preoperative modified geriatric nutritional risk index (mGNRI) values with prognosis in patients receiving surgery for oral cavity squamous cell carcinoma (OCSCC). This retrospective study analyzed the clinical data of 333 patients with OCSCC and undergoing surgery between 2008 and 2017. The preoperative mGNRI was calculated using the following formula: (14.89/C-reactive protein level) + 41.7 × (actual body weight/ideal body weight). We executed receiver operating characteristic curve analyses to derive the optimal mGNRI cutoff and employed Kaplan–Meier survival curves and Cox proportional hazard model to probe the associations of the mGNRI with overall survival (OS) and disease-free survival (DFS). The optimal mGNRI cutoff was derived to be 73.3. We noted the 5-year OS and DFS rates to be significantly higher in the high-mGNRI group than in the low-mGNRI group (both p < 0.001). A preoperative mGNRI below 73.3 was independently associated with unfavorable DFS and OS. A mGNRI-based nomogram was constructed to provide accurate OS predictions (concordance index, 0.781). Hence, preoperative mGNRI is a valuable and cost-effective prognostic biomarker in patients with OCSCC. Our nomogram facilitates the practical use of mGNRI and offers individualized predictions of OS.
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1 Chang Gung Memorial Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Chiayi, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593); Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922)
2 Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922); Chang Gung Memorial Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593)
3 Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922); Chang Gung Memorial Hospital, Department of Hematology and Oncology, Chiayi, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593)
4 Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922); Chang Gung Memorial Hospital, Department of Radiation Oncology, Chiayi, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593)
5 Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922); Chang Gung Memorial Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Taoyuan, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593)
6 Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922); Chang Gung Memorial Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Keelung, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593)
7 Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922); Chang Gung Memorial Hospital, Department of Diagnostic Radiology, Chiayi, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593)
8 Chang Gung University, College of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a) (ISNI:0000 0004 1798 0922); Chang Gung Memorial Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Taoyuan, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593); Chang Gung Memorial Hospital, Puzi City, Taiwan (GRID:grid.413801.f) (ISNI:0000 0001 0711 0593)