Perturbations of Metabolic Protein Kinase Signaling in Disorders of Cognition

Abstract

Protein kinases and their signaling networks orchestrate cell survival, function, and activity. In the “omics” era, studying the transcriptome, the proteome, and the metabolome provide detailed information on the perturbations in human disease. The research herein attempts to expand our understanding of two human neuropsychiatric disorders, schizophrenia and Alzheimer’s Disease, by evaluating the “kinome.” The kinome describes the state of functional kinase activity en masse in biological systems. With the kinome, this Dissertation characterizes, implicates, and describes how protein kinases implicated in metabolic functioning are impaired in these devastating and debilitating disorders.