Abstract

Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.

Recently, studies have identified different low-density lipoprotein receptors as functional entry receptors for alphaviruses. In this Perspective, the authors compare the known alphavirus-receptor structures and discuss why it might be challenging to generate a broad-spectrum entry inhibitor.

Details

Title
LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy
Author
Wang, Ningning 1 ; Merits, Andres 2 ; Veit, Michael 3   VIAFID ORCID Logo  ; Lello, Laura Sandra 2 ; Kong, Shuhan 1 ; Jiao, Houqi 1 ; Chen, Jie 1 ; Wang, Yu 1 ; Dobrikov, Georgi 4 ; Rey, Félix A. 5   VIAFID ORCID Logo  ; Su, Shuo 6 

1  Nanjing Agricultural University, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing, China (GRID:grid.27871.3b) (ISNI:0000 0000 9750 7019) 
2  University of Tartu, Institute of Bioengineering, Tartu, Estonia (GRID:grid.10939.32) (ISNI:0000 0001 0943 7661) 
3  Free University Berlin, Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Berlin, Germany (GRID:grid.14095.39) (ISNI:0000 0000 9116 4836) 
4  Bulgarian Academy of Sciences, Institute of Organic Chemistry with Centre of Phytochemistry, Sofia, Bulgaria (GRID:grid.410344.6) (ISNI:0000 0001 2097 3094) 
5  CNRS UMR 3569, 25-28 Rue du Docteur Roux, 75724 Paris Cedex 15, Institut Pasteur, Unité de Virologie Structurale, Department Virologie, Paris, France (GRID:grid.428999.7) (ISNI:0000 0001 2353 6535) 
6  Nanjing Agricultural University, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing, China (GRID:grid.27871.3b) (ISNI:0000 0000 9750 7019); Nanjing Agricultural University, Sanya Institute of Nanjing Agricultural University, Sanya, China (GRID:grid.27871.3b) (ISNI:0000 0000 9750 7019) 
Pages
4906
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-024-49301-1
ProQuest document ID
3065628846
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.