It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
OPFRs are emerging environmental pollutants with reproductive and endocrine toxicity. This study aimed to examine the association between environmental exposure to OPFRs during early pregnancy and GDM. This nested case–control study was based on a birth cohort that was constructed at a maternal and child health hospital, including 74 cases of GDM among 512 pregnant women. The OPFRs, including TBP, TBEP, TCEP, TDCPP, TMCP, TOCP, and TPHP during 10–14 weeks of pregnancy were determined using GC–MS. The association between the OPFRs and GDM was assessed using WQS and BKMR models. The levels of OPFRs were significantly elevated in GDM patients (60) compared with the controls (90). The WQS analysis showed that mixtures of the OPFRs were significantly associated with GDM (OR 1.370, 95% CI 1.036–1.810, P = 0.027), and TBP, TPHP, and TMCP were the major contributors to the mixed exposure effect. In the BKMR model, individual exposure to TBP, TPHP, and TMCP, and the interaction of TMCP with TBP and TPHP were significantly associated with GDM. Environmental exposure to OPFRs is positively associated with GDM. These findings provide evidence for the adverse effects of OPFR exposure on the health of pregnant women.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 First Affiliated Hospital of Guilin Medical University, Clinical Laboratory Center, Guilin, China (GRID:grid.443385.d) (ISNI:0000 0004 1798 9548)
2 Guilin Medical University, Guangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin, China (GRID:grid.443385.d) (ISNI:0000 0004 1798 9548)
3 Xin Hua Hospital, Shanghai JiaoTong University School of Medicine, Ministry of Education and Shanghai Key Laboratory of Children’s Environmental Health, Shanghai, China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293)
4 Liuzhou Maternity and Child Healthcare Hospital, Guangxi Health Commission Key Laboratory of Birth Cohort Study in Pregnant Women With Advanced Age, Liuzhou, China (GRID:grid.477238.d)