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Abstract

Like the letters in the alphabet forming words, reusing components of a heterogeneous mixture is an efficient strategy for assembling a large number of target structures. Examples range from synthetic DNA origami to proteins self-assembling into complexes. The standard self-assembly paradigm views target structures as free-energy minima of a mixture. While this is an appealing picture, at high speed structures may be kinetically trapped in local minima, reducing self-assembly accuracy. How then can high speed, high accuracy, and combinatorial usage of components coexist? We propose to reconcile these three concepts not by avoiding kinetic traps, but by exploiting them to encode target structures. This can be achieved by sculpting the kinetic pathways of the mixture, instead of its free-energy landscape. We formalize these ideas in a minimal toy model, for which we analytically estimate the encoding capacity and kinetic characteristics, in agreement with simulations. Our results may be generalized to other soft-matter systems capable of computation, such as liquid mixtures or elastic networks, and pave the way for high-dimensional information processing far from equilibrium.

Details

1009240
Identifier / keyword
Title
High-Speed Combinatorial Polymerization through Kinetic-Trap Encoding
Publication title
arXiv.org; Ithaca
Publication year
2024
Publication date
Dec 9, 2024
Section
Condensed Matter
Publisher
Cornell University Library, arXiv.org
Source
arXiv.org
Place of publication
Ithaca
Country of publication
United States
University/institution
Cornell University Library arXiv.org
e-ISSN
2331-8422
Source type
Working Paper
Language of publication
English
Document type
Working Paper
Publication history
 
 
Online publication date
2024-12-10
Milestone dates
2024-06-26 (Submission v1); 2024-07-26 (Submission v2); 2024-08-09 (Submission v3); 2024-12-09 (Submission v4)
Publication history
 
 
   First posting date
10 Dec 2024
ProQuest document ID
3072927893
Document URL
https://www.proquest.com/working-papers/high-speed-combinatorial-polymerization-through/docview/3072927893/se-2?accountid=208611
Full text outside of ProQuest
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2024-12-11
Database
ProQuest One Academic