It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Presbycusis, or age-related hearing loss, affects both elderly humans and dogs, significantly impairing their social interactions and cognition. In humans, presbycusis involves changes in peripheral and central auditory systems, with central changes potentially occurring independently. While peripheral presbycusis in dogs is well-documented, research on central changes remains limited. Diffusion tensor imaging (DTI) is a useful tool for detecting and quantifying cerebral white matter abnormalities. This study used DTI to explore the central auditory pathway of senior dogs, aiming to enhance our understanding of canine presbycusis. Dogs beyond 75% of their expected lifespan were recruited and screened with brainstem auditory evoked response testing to select dogs without severe peripheral hearing loss. Sixteen dogs meeting the criteria were scanned using a 3 T magnetic resonance scanner. Tract-based spatial statistics was used to analyze the central auditory pathways. A significant negative correlation between fractional lifespan and fractional anisotropy was found in the acoustic radiation, suggesting age-related white matter changes in the central auditory system. These changes, observed in dogs without severe peripheral hearing loss, may contribute to central presbycusis development.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 North Carolina State University, Department of Clinical Sciences, College of Veterinary Medicine, Raleigh, USA (GRID:grid.40803.3f) (ISNI:0000 0001 2173 6074)
2 University of North Carolina at Chapel Hill, Department of Radiology and Biomedical Research Imaging Center (BRIC), Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208)
3 Nanjing University of Science and Technology, School of Computer Science and Engineering, Nanjing, China (GRID:grid.410579.e) (ISNI:0000 0000 9116 9901)
4 North Carolina State University, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, Raleigh, USA (GRID:grid.40803.3f) (ISNI:0000 0001 2173 6074)
5 North Carolina State University, Department of Clinical Sciences, College of Veterinary Medicine, Raleigh, USA (GRID:grid.40803.3f) (ISNI:0000 0001 2173 6074); North Carolina State University, Comparative Medicine Institute, Raleigh, USA (GRID:grid.40803.3f) (ISNI:0000 0001 2173 6074)