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Abstract
Fucosterols have been widely studied for their antioxidant, anticancer, and anti-inflammatory properties. However, they have not yet been studied in the field of dentistry. This study aimed to determine whether pretreatment of dentin with fucosterol before resin restoration enhances bond stability in resin-dentin hybrid layers. After applying 0.1, 0.5, and 1.0 wt% fucosterol to demineralized dentin, microtensile bond strength (MTBS) and nanoleakage tests were performed before and after collagenase aging, and the surface was observed using scanning electron microscope (SEM). The fucosterol-treated group showed better bond strength and less nanoleakage both before and after collagenase aging, and the corresponding structures were confirmed using SEM. MMP zymography confirmed that the activity of MMPs was relatively low along the concentration gradient of fucosterol, and the FTIR analysis confirmed the production of collagen crosslinks. In addition, fucosterol exhibits cytotoxicity against Streptococcus mutans, the main cause of dental decay. The results of this study suggest that fucosterol pretreatment improves bond strength and reduces nanoleakage at the resin-dentin interface, possibly through a mechanism involving collagen cross-link formation via the inhibition of endogenous and exogenous MMP activity. This study demonstrates the potential of fucosterol as an MMP inhibitor in dentin, which contributes to long-term resin-dentin bond stability and can be used as a restorative material.
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1 Pusan National University, Department of Orthodontics, Dental Research Institute, Yangsan, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572)
2 Pusan National University, Department of Oral Physiology, School of Dentistry, Yangsan, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572)
3 School of Engineering, The University of Tokyo, Institute of Engineering Innovation, Tokyo, Japan (GRID:grid.26999.3d) (ISNI:0000 0001 2169 1048)
4 Pusan National University, School of Materials Science and Engineering, Busan, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572)
5 School of Dentistry, Pusan National University, Periodontal Disease Signaling Network Research Center (MRC), Yangsan, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572)
6 School of Dentistry, Pusan National University, Department of Oral Anatomy, Yangsan, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572)
7 Pusan National University, Department of Orthodontics, Dental Research Institute, Yangsan, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572); Dental and Life Science Institute, Pusan National University, Yangsan, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572)