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ABSTRACT:
Background: Hypertension which is having increased mortality risk affects various systems of the body and increases the risk of cardiovascular disease, impairment in renal function. Siddha system plays an important role in treating and managing hypertension and its risk. Objective: To find the efficacy of the Siddha formulation against the enzymatic action of the Angiotensin-converting enzyme (ACE) that has higher level of significance in the management of blood pressure. Methods: The molecular docking study was used for docking against Human angiotensin converting enzyme. Results: The leads such as Oleic acid, Vitexin, Rutin, Luteolin, Gallic acid, Corilagin and Maslinic acid reveals maximum of 7 to 10 interactions with the core active amino acid residues present on the target ACE in comparison with standard drug Captopril which reveals 9 interactions over the target enzyme. Conclusion: The bio-active compound's present in the Siddha formulation reveals significant binding against the target protein Angiotensin converting enzyme by interacting with active amino acid present on the active site thereby it can be concluded that these compounds may exert promising anti-hypertensive activity.
KEYWORDS: Siddha, In-silico, Angiotensin converting enzyme, anti-hypertensive, Justiciabeddomei, Rutin
INTRODUCTION:
Hypertension is a major reason for cardiovascular diseases and other systemic condition.Low and middleincome countries have increased prevalence of hypertension. The risk factors for hypertension are high sodium intake, low potassium intake, obesity, alcohol consumption, physical inactivity and unhealthy diet 1 . Hypertension affects various systems of the body and increases the risk of cardiovascular diseases such as myocardial infarction, heart failure, renal dysfunction, and increased mortality risk. In worldwide, HTN affects nearly 1.3 billion people, and two-thirds of people belong to low and middle-income countries.
The past two decades, the highest prevalence of HTN shifted from high-to middle-income countries to low and middle-income countries, attributed to multiple factors such as lifestyle changes. In India prevalence of hypertension is 29.8 %. It varies from 27.6 % to 33.8 % in rural and urban settings. The elderly patients were affected more than other age group patients, which was predominantly more in male patients than in female patients2 .
Pre-hypertension produces pathological changes in the vascularization and hypertrophy of the left ventricle. Stroke and Heart failure is the main risk factor of hypertension3 . Patients with Chronic Kidney Disease, treatment...