Abstract

Background

Poor memory for treatment is associated with poorer treatment adherence and poorer patient outcomes. The memory support intervention (MSI) was developed to improve patient memory for treatment with the goal of improving patient outcomes. The aim of this study protocol is to conduct a confirmatory efficacy trial to test whether a new, streamlined, and potent version of the MSI improves outcomes for midlife and older adults. This streamlined MSI is comprised of constructive memory supports that will be applied to a broader range of treatment content. The platform for this study is the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C). We will focus on midlife and older adults who are low income and experiencing mobility impairments.

Methods

Participants (N = 178) will be randomly allocated to TranS-C + MSI or TranS-C alone. Both intervention arms include eight 50-min weekly sessions. Assessments will be conducted at pre-treatment, post-treatment, 6-, and 12-month follow-up (6FU and 12FU). Aim 1 will compare the effects of TranS-C + MSI versus TranS-C alone on sleep and circadian functioning, daytime functioning, well-being, and patient memory. Aim 2 will test whether patient memory for treatment mediates the relationship between treatment condition and patient outcomes. Aim 3 will evaluate if previously reported poor treatment response subgroups will moderate the relationship between treatment condition and (a) patient memory for treatment and (b) treatment outcome. Exploratory analyses will compare treatment condition on (a) patient adherence, patient-rated treatment credibility, and patient utilization of treatment contents, and (b) provider-rated acceptability, appropriateness, and feasibility.

Discussion

This study has the potential to provide evidence for (a) the efficacy of a new simplified version of the MSI for maintaining health, well-being, and functioning, (b) the wider application of the MSI for midlife and older adults and to the treatment of sleep and circadian problems, and (c) the efficacy of the MSI for sub-groups who are likely to benefit from the intervention.

Trial registration

ClinicalTrials.gov NCT05986604. Registered on 2 August 2023.

Details

Title
Integrating the Memory Support Intervention into the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C): can improving memory for treatment in midlife and older adults improve patient outcomes? Study protocol for a randomized controlled trial
Author
Milner, Anne E. 1 ; Hache, Rafael Esteva 1 ; Oliver, Sophia 1 ; Sarfan, Laurel D. 1 ; Spencer, Julia M. 1 ; Cogan, Ashby 1 ; Jiang, Yimei 1 ; Agnew, Emma R. 1 ; Zieve, Garret G. 2 ; Martin, Jennifer L. 3 ; Zeidler, Michelle R. 4 ; Dong, Lu 5 ; Carpenter, Joseph K. 6 ; Varghese, Joshua 1 ; Bol, Kiely 1 ; Bajwa, Zia 1 ; Tighe, Caitlan A. 7 ; Harvey, Allison G. 1   VIAFID ORCID Logo 

1  University of California, Department of Psychology, Berkeley, USA (GRID:grid.47840.3f) (ISNI:0000 0001 2181 7878) 
2  Oakland Cognitive Behavior Therapy Center, Oakland, USA (GRID:grid.47840.3f) 
3  Geriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, USA (GRID:grid.417119.b) (ISNI:0000 0001 0384 5381); David Geffen School of Medicine at the University of California, Department of Medicine, Los Angeles, USA (GRID:grid.19006.3e) (ISNI:0000 0000 9632 6718) 
4  UCLA Health Pulmonology, Los Angeles, USA (GRID:grid.417816.d) (ISNI:0000 0004 0392 6765) 
5  RAND Corporation, Behavioral and Policy Sciences, Santa Monica, USA (GRID:grid.34474.30) (ISNI:0000 0004 0370 7685) 
6  Women’s Health Sciences Division, VA Boston Healthcare System, National Center for PTSD, Boston, USA (GRID:grid.410370.1) (ISNI:0000 0004 4657 1992) 
7  Providence College, Department of Psychology, Providence, USA (GRID:grid.418778.5) (ISNI:0000 0000 9812 3543) 
Pages
650
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
e-ISSN
17456215
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13063-024-08468-0
ProQuest document ID
3112664455
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.