Abstract

The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37–0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.

Details

Title
Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study
Author
Denos, Marion 1   VIAFID ORCID Logo  ; Sun, Yi-Qian 2 ; Brumpton, Ben Michael 3 ; Li, Yafang 4 ; Albanes, Demetrius 5 ; Burnett-Hartman, Andrea 6 ; Campbell, Peter T. 7 ; Küry, Sébastien 8 ; Li, Christopher I. 9 ; White, Emily 9 ; Samadder, Jewel N. 10 ; Jenkins, Mark A. 11 ; Mai, Xiao-Mei 1 

1  Norwegian University of Science and Technology, Department of Public Health and Nursing, Trondheim, Norway (GRID:grid.5947.f) (ISNI:0000 0001 1516 2393) 
2  Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Trondheim, Norway (GRID:grid.5947.f) (ISNI:0000 0001 1516 2393); St. Olavs Hospital, Department of Pathology, Clinic of Laboratory Medicine, Trondheim, Norway (GRID:grid.52522.32) (ISNI:0000 0004 0627 3560); Center for Oral Health Services and Research Mid-Norway (TkMidt), Trondheim, Norway (GRID:grid.52522.32) 
3  Norwegian University of Science and Technology, Department of Public Health and Nursing, K.G. Jebsen Centre for Genetic Epidemiology, Trondheim, Norway (GRID:grid.5947.f) (ISNI:0000 0001 1516 2393); NTNU, Norwegian University of Science and Technology, Department of Public Health and Nursing, HUNT Research Centre, Levanger, Norway (GRID:grid.5947.f) (ISNI:0000 0001 1516 2393); Trondheim University Hospital, Clinic of Medicine, St. Olavs Hospital, Trondheim, Norway (GRID:grid.52522.32) (ISNI:0000 0004 0627 3560) 
4  Baylor College of Medicine, Institute for Clinical and Translational Research, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X) 
5  National Cancer Institute, National Institutes of Health, Division of Cancer Epidemiology and Genetics, Bethesda, USA (GRID:grid.48336.3a) (ISNI:0000 0004 1936 8075) 
6  Institute for Health Research, Kaiser Permanente Colorado, Denver, USA (GRID:grid.280062.e) (ISNI:0000 0000 9957 7758) 
7  Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, USA (GRID:grid.251993.5) (ISNI:0000 0001 2179 1997) 
8  Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France (GRID:grid.4817.a) (ISNI:0000 0001 2189 0784) 
9  Fred Hutchinson Cancer Center, Public Health Sciences Division, Seattle, USA (GRID:grid.270240.3) (ISNI:0000 0001 2180 1622) 
10  Mayo Clinic, Department of Gastroenterology and Hepatology, Scottsdale, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X) 
11  The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X) 
Pages
23891
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-024-75305-4
ProQuest document ID
3115836568
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.