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Keywords: Early breast tumors; surgery, radiotherapy treatment, radiation dermatitis, risk factors.
ABSTRACT
Background: Building a risk prediction model, validating it, and researching the risk variables for radiation dermatitis in patients receiving post-operative radiotherapy for early breast cancer. Materials and Methods: A total of 326 patients with early-stage breast cancer who underwent postoperative radiotherapy in hospital between August 2020 and August 2023 were selected and divided into 198 in the modeling group and 128 in the validation group; and the modeling group was divided into an occurrence group and a non-occurrence group according to whether they had radiation dermatitis. Logistic regression was used to investigate the risk factors for the development of dermatitis, and the predictive effect of the model was tested by the receiver operating characteristic curve (ROC). Results: Combined diabetes, conventional split radiotherapy, compensatory membrane application, and albumin <40g/L were independent risk factors for radiation dermatitis (P < 0.05); the area under the curve (AUC) was 0.821 and 0.908 in the modeling and validation groups, respectively, P < 0.001, with goodness-of-fit test (Hosmer-Leme-show, H-L) validity. Conclusion: Clinically, it is important to consider the risk factors of radiation dermatitis among patients who receive postoperative radiotherapy for early-stage breast cancer. Utilizing a risk prediction model, doctors can identify and evaluate patients' risk levels, aiding in the timely implementation of preventive measures.
INTRODUCTION
One of the most common malignancies in women is breast cancer (BC). Global data survey (1) shows that the incidence rate of BC can reach 11.7% in 2020, and it shows a trend of increasing year by year. Domestic data shows & that the incidence of cancer in female patients can reach 16%, threatening women's health and lives. Surgery with adjuvant radiotherapy and chemotherapy is currently an important means of treating BC. Cancer lesions are removed through surgery and the cancer cells are completely killed through the adjuvant means of radiotherapy and chemotherapy, thus enhancing the cancer recovery rate. While treatment maximizes control of the disease, radiotherapy treatment is administered to increase the incidence of adverse effects during treatment. Both conventional 2D fractionated and 3D Intensity modulated radiation therapy (IMRT) are commonly used in clinical radiotherapy treatment. Studies have shown © that both types of radiotherapy are equally effective in treating the disease,...