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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background/Objectives: Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and mental health issues. It affects approximately 1.78% of the general population; an estimated 4:1 ratio between women and men is observed. It significantly impacts quality of life and carries both clinical and social stigma. This study aims to evaluate the relationship between drug use and mental health in female patients with fibromyalgia. Methods: This study is prospective, observational, and cross-sectional. A questionnaire was administered to 544 subjects, achieving a representative sample size from a population of 800,000 subjects by using an algorithm for proportion estimation with a known sampling frame. The selection was non-random, making the sampling non-probabilistic. Logistic regression models were applied to assess the effect of drug use on perception of mental health; presence of symptoms such as comprehension and memory problems, insomnia, depression, and anxiety; and severity of cognitive symptoms and non-restorative sleep. To quantify the impact, odds ratios and confidence intervals have been observed. Results: The findings indicate the non-recommended use of medications and reveal the ineffectiveness and adverse effects of drug interactions on mental health. The use of benzodiazepines and sedative-hypnotics is significantly associated with a negative perception of mental health. Benzodiazepines do not improve symptoms or significantly reduce their severity. SSRI antidepressants do not enhance mental health perception; however, when used exclusively, they are effective in reducing the severity, but not the prevalence, of cognitive symptoms. Conclusions: The results highlight the complexity of pharmacological management in FM and raise concerns about the inappropriate use of ineffective or counterproductive drug interactions affecting patients’ mental health. They underscore the need for multidisciplinary and personalized strategies that include close and careful monitoring, as well as the simultaneous use of non-pharmacological treatments that have demonstrated evidence in improving quality of life without negatively affecting mental health, such as patient education, psychological therapy, physiotherapy, and mindfulness.

Details

Title
Association between Drug Use and Perception of Mental Health in Women Diagnosed with Fibromyalgia: An Observational Study
Author
Lizama-Lefno, Andrea 1 ; Mojica, Krystel 2   VIAFID ORCID Logo  ; Roco-Videla, Ángel 3   VIAFID ORCID Logo  ; Vargas Ruiz-Tagle, Juan Ignacio 4   VIAFID ORCID Logo  ; González-Droguett, Nelia 2   VIAFID ORCID Logo  ; María Jesús Muñoz-Yánez 5   VIAFID ORCID Logo  ; Atenas-Núñez, Erick 5   VIAFID ORCID Logo  ; Nelson Maureira-Carsalade 6   VIAFID ORCID Logo  ; Sergio Flores Carrasco 7 

 Dirección de Desarrollo y Postgrados, Universidad Autónoma de Chile, Galvarino Gallardo 1983, Santiago 7500138, Chile; [email protected] 
 Fundación Núcleo de Investigación DOLMEN, El Director 6000, Of. 207, Las Condes, Santiago 7580023, Chile; [email protected] (K.M.); [email protected] (N.G.-D.) 
 Vicerrectoría de Investigación e Innovación, Universidad Arturo Prat, Iquique 1110939, Chile; [email protected] 
 Clínica Andes Salud, Bellavista 123, Puerto Montt 5480000, Chile; [email protected] 
 Universidad Gabriela Mistral, Av. Andrés Bello 1337, Santiago 7500533, Chile; [email protected] (M.J.M.-Y.); [email protected] (E.A.-N.) 
 Facultad de Ingeniería, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile; [email protected] 
 Instituto de Geografía, Universidad Católica de Valparaíso, Valparaíso 2340000, Chile 
First page
2284
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
22279059
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3120605232
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.