Abstract

An unusual NBS promoted cascade reaction of β-anhydroicaritine and alcohols was successfully developed to prepare chromane-3,4-dione 3 in a moderate yield. A mechanism was also put forward to explain this reaction. These chromane-3,4-dione derivatives showed a potent cytotoxicity against HepG2 and MCF-7 cell lines, which were expected to be a potential lead candidate for the treatment of liver cancer and breast cancer.

Details

Title
NBS promoted cascade reaction of β-anhydroicaritine and alcohols
Author
Cui, Hanqi 1 ; Wang, Xianheng 1 ; Qian, Shuang 1   VIAFID ORCID Logo  ; He, Yuqi 2   VIAFID ORCID Logo  ; Zhao, Changkuo 1 

1  Department of Medicinal Chemistry, Zunyi Medical University, Zunyi, People’s Republic of China 
2  Department of Pharmaceutical Analysis, Zunyi Medical University, Zunyi, People’s Republic of China 
Publication year
2023
Publication date
Mar 2023
Publisher
Taylor & Francis Ltd.
ISSN
17518253
e-ISSN
17517192
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/17518253.2022.2148836
ProQuest document ID
3121541933
Copyright
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.