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© 2024. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background:Antimicrobial resistance (AMR) is a major global public health concern, particularly in low- and middle-income countries where resources and infrastructure for an adequate response are limited. The World Health Organization (WHO) Global Antimicrobial Resistance Surveillance System (GLASS) was introduced in 2016 to address these challenges, outlining recommendations for priority pathogen-antibiotic combinations. Despite this initiative, implementation in Africa remains understudied. This scoping review aims to assess the current state of implementing WHO GLASS recommendations on antimicrobial sensitivity testing (AST) in Africa.

Objective:The primary objective of this study is to determine the current state of implementing the WHO GLASS recommendations on AST for priority pathogen-antimicrobial combinations. The review will further document if the reporting of AST results is according to “susceptible,” “intermediate,” and “resistant” recommendations according to GLASS.

Methods:Following the methodological framework by Arksey and O’Malley, studies published between January 2016 and November 2023 will be included. Search strategies will target electronic databases, including MEDLINE, Scopus, CINAHL, and Embase. Eligible studies will document isolates tested for antimicrobial sensitivity, focusing on WHO-priority specimens and pathogens. Data extraction will focus on key study characteristics, study context, population, and adherence to WHO GLASS recommendations on AST. Descriptive statistics involving summarizing the quantitative data extracted through measures of central tendency and variation will be used. Covidence and Microsoft Excel software will be used. This study will systematically identify, collate, and analyze relevant studies and data sources based on clear inclusion criteria to provide a clear picture of the progress achieved in the implementation of the WHO GLASS recommendations. Areas for further improvement will be documented to inform future efforts to strengthen GLASS implementation for enhanced AMR surveillance in Africa.

Results:The study results are expected in August 2024.

Conclusions:To our knowledge, this scoping review will be the first to comprehensively examine the implementation of WHO GLASS recommendations in Africa, shedding light on the challenges and successes of AMR surveillance in the region. Addressing these issues aims to contribute to global efforts to combat AMR.

International Registered Report Identifier (IRRID):PRR1-10.2196/58140

Details

Title
Progress of Implementation of World Health Organization Global Antimicrobial Resistance Surveillance System Recommendations on Priority Pathogen-Antibiotic Sensitivity Testing in Africa: Protocol for a Scoping Review
Author
Mackline Hope  VIAFID ORCID Logo  ; Kiggundu, Reuben  VIAFID ORCID Logo  ; Byonanebye, Dathan M  VIAFID ORCID Logo  ; Mayito, Jonathan  VIAFID ORCID Logo  ; Dickson Tabajjwa  VIAFID ORCID Logo  ; Lwigale, Fahad  VIAFID ORCID Logo  ; Tumwine, Conrad  VIAFID ORCID Logo  ; Mwanja, Herman  VIAFID ORCID Logo  ; Kambugu, Andrew  VIAFID ORCID Logo  ; Kakooza, Francis  VIAFID ORCID Logo 
First page
e58140
Section
Scoping Review Protocols
Publication year
2024
Publication date
2024
Publisher
JMIR Publications
e-ISSN
19290748
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3132298693
Copyright
© 2024. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.