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Abstract

Image registration is a core task in computational anatomy that establishes correspondences between images. Invertible deformable registration, which computes a deformation field and handles complex, non-linear transformation, is essential for tracking anatomical variations, especially in neuroimaging applications where inter-subject differences and longitudinal changes are key. Analyzing the deformation fields is challenging due to their non-linearity, limiting statistical analysis. However, traditional approaches for analyzing deformation fields are computationally expensive, sensitive to initialization, and prone to numerical errors, especially when the deformation is far from the identity. To address these limitations, we propose the Log-Euclidean Diffeomorphic Autoencoder (LEDA), an innovative framework designed to compute the principal logarithm of deformation fields by efficiently predicting consecutive square roots. LEDA operates within a linearized latent space that adheres to the diffeomorphisms group action laws, enhancing our model's robustness and applicability. We also introduce a loss function to enforce inverse consistency, ensuring accurate latent representations of deformation fields. Extensive experiments with the OASIS-1 dataset demonstrate the effectiveness of LEDA in accurately modeling and analyzing complex non-linear deformations while maintaining inverse consistency. Additionally, we evaluate its ability to capture and incorporate clinical variables, enhancing its relevance for clinical applications.

Details

1009240
Title
LEDA: Log-Euclidean Diffeomorphic Autoencoder for Efficient Statistical Analysis of Diffeomorphism
Publication title
arXiv.org; Ithaca
Publication year
2024
Publication date
Dec 20, 2024
Section
Computer Science
Publisher
Cornell University Library, arXiv.org
Source
arXiv.org
Place of publication
Ithaca
Country of publication
United States
University/institution
Cornell University Library arXiv.org
e-ISSN
2331-8422
Source type
Working Paper
Language of publication
English
Document type
Working Paper
Publication history
 
 
Online publication date
2024-12-23
Milestone dates
2024-12-20 (Submission v1)
Publication history
 
 
   First posting date
23 Dec 2024
ProQuest document ID
3148681132
Document URL
https://www.proquest.com/working-papers/leda-log-euclidean-diffeomorphic-autoencoder/docview/3148681132/se-2?accountid=208611
Full text outside of ProQuest
Copyright
© 2024. This work is published under http://arxiv.org/licenses/nonexclusive-distrib/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2024-12-24
Database
ProQuest One Academic