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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Little is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and diosmetin) on hair were investigated according to the sequential processes of hair graying that were previously clarified in model mice [Ednrb(+/−);RET-mice]. External treatment with luteolin, but not that with hesperetin or diosmetin, alleviated hair graying in Ednrb(+/−);RET-mice. Internal treatment with luteolin also mitigated hair graying in the mice. Although both luteolin treatments had very limited effects on hair cycles, the treatments suppressed the increase in p16ink4a-positive cells in bulges [senescent keratinocyte stem cells (KSCs)]. Both of the treatments also suppressed decreases in the expression levels of endothelins in KSCs and their receptor (Ednrb) in melanocyte stem cells (MSCs) and alleviated hair graying in the mice. Luteolin is a special antioxidant with an anti-graying potency through improvement of age-related dysfunction in signaling between endothelins in KSCs and their receptor in MSCs. Luteolin for topical and oral use is commercially available to people in the form of supplements. Similar processes of hair graying in Ednrb(+/−);RET-mice and humans have been reported. These results are encouraging for the practical application of luteolin as a medicine with an anti-graying effect on hair in humans.

Details

Title
Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice
Author
Iida, Machiko 1   VIAFID ORCID Logo  ; Kagawa, Takumi 2 ; Yajima, Ichiro 1   VIAFID ORCID Logo  ; Harusato, Akihito 2 ; Tazaki, Akira 3   VIAFID ORCID Logo  ; Delgama A S M Nishadhi 2 ; Taguchi, Nobuhiko 4   VIAFID ORCID Logo  ; Kato, Masashi 5   VIAFID ORCID Logo 

 Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; [email protected] (M.I.); [email protected] (T.K.); [email protected] (A.H.); [email protected] (D.A.S.M.N.); Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai-shi 487-8501, Japan 
 Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; [email protected] (M.I.); [email protected] (T.K.); [email protected] (A.H.); [email protected] (D.A.S.M.N.) 
 Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; [email protected] (M.I.); [email protected] (T.K.); [email protected] (A.H.); [email protected] (D.A.S.M.N.); Activities of the Institute of Innovation for Future Society, Nagoya University, Nagoya 464-8601, Japan 
 Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai-shi 487-8501, Japan; General Research and Development Institute, Hoyu Co., Ltd., 1-12 Rouboku, Nagakute-shi 480-1136, Japan 
 Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; [email protected] (M.I.); [email protected] (T.K.); [email protected] (A.H.); [email protected] (D.A.S.M.N.); Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai-shi 487-8501, Japan; Activities of the Institute of Innovation for Future Society, Nagoya University, Nagoya 464-8601, Japan 
First page
1549
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
20763921
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3149501556
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.