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Abstract
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.
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Details
1 Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava Slovakia; Comenius University Bratislava, Jessenius Faculty of Medicine in Martin, Department of Pharmacology, BioMed, Martin,Slovakia
2 Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava,Slovakia
3 Research Center of Neurology, Moscow, Russian Federation
4 Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava Slovakia; Comenius University in Bratislava, Faculty of Pharmacy, Department of Galenic Pharmacy, Bratislava, Slovakia