Content area
The use of medicinal plants represents an alternative method for bacterial control due to their chemical compositions. This study’s objective was to determine the inhibitory capacity of Larrea tridentata extracts against microbial strains of clinical interest. Four extracts were prepared, their phytochemical profiles were determined, and their antioxidant capacities were quantified. Additionally, the minimum concentrations of hemolysis were determined using human blood erythrocytes. For the extracts’ growth inhibitory capacity, six bacterial and two fungal strains were evaluated using the disk diffusion test. Commercial medications specific for each strain were used as controls. The ethanolic extracts registered the greatest diversity of metabolites related to antibacterial activity. The inhibitory activities of the ethanolic extract and the Cedax® control were similar for Enterococcus faecalis. A principal component analysis was performed with X2 and ANOVA tests to identify the relationships and the effects of the extracts on bacterial inhibition, obtaining p > 0.05 with a confidence level of 95%. This research highlights the potential of L. tridentata extracts as an alternative treatment and to mitigate the growing problem of resistance to traditional antibiotics.
Details
; Esparza-Orozco, Alfredo 1
; Delgadillo-Ruiz, Eladio 2
; Bañuelos-Valenzuela, Rómulo 3 ; Valladares-Carranza, Benjamín 4
; Chávez-Ruvalcaba, María Isabel 1 ; Chávez-Ruvalcaba, Francisca 5
; Valtierra-Marín, Héctor Emmanuel 6
; Gaytán-Saldaña, Norma Angélica 1
; Mercado-Reyes, Marisa 1
; Arias-Hernández, Luz Adriana 2
1 Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Av. Preparatoria, Agronómica, Zacatecas 98068, Mexico;
2 Department of Civil and Environmental Engineering, Engineering Division, University of Guanajuato, Av. Juárez, Col. Centro, Guanajuato 36000, Mexico;
3 Academic Unit of Veterinary Medicine and Animal Husbandry, Autonomous University of Zacatecas, Kilómetro 31.5 Carretera Zacatecas-Fresnillo, Enrique Estrada, Zacatecas 98502, Mexico;
4 Center for Research and Advanced Studies in Animal Health, Autonomous University of the State of Mexico, Toluca 50200, Mexico;
5 Academic Unit of Nutrition, Autonomous University of Zacatecas, Carretera Zacatecas-Guadalajara, Km 6, Ejido la Escondida, Zacatecas 98160, Mexico;
6 Academic Unit of Agronomy, Autonomous University of Zacatecas, Carretera Federal 54 Km 15.5, Zacatecas 98170, Mexico;