Abstract

Rituximab (RTX) is a chimeric monoclonal antibody against CD20+ B cells increasingly used to treat kidney disorders. RTX-induced pulmonary disease has been reported in patients treated for haematological disorders, and a few cases have been observed in patients with underlying rheumatological conditions. We report a case of non-infectious interstitial pneumonitis associated with RTX use in a 49-year-old patient with primary (fibrillary) glomerulonephritis. As typically observed, discontinuation of the drug and prompt initiation of glucocorticoids led to resolution of pulmonary manifestations. However, fatalities have been reported and nephrologists treating glomerulonephritis patients with RTX should be aware of the existence of this potentially lethal complication.

Details

Title
Rituximab-associated interstitial lung disease in fibrillary glomerulonephritis
Author
Sainz-Prestel, Valeria 1 ; Hernandez-Perez, Jesus 1 ; Rojas-Rivera, Jorge 1 ; Milicua-Muñoz, José María 2 ; Egido, Jesus 3 ; Ortiz, Alberto 1 

 Nephrology, IIS-Fundación Jimenez Diaz/UAM/IRSIN, Madrid, Spain; REDINREN 
 Pathology, IIS-Fundación Jimenez Diaz/UAM/IRSIN, Madrid, Spain; ICU, IIS-Fundación Jimenez Diaz/UAM, Madrid, Spain 
 Nephrology, IIS-Fundación Jimenez Diaz/UAM/IRSIN, Madrid, Spain 
Pages
510-512
Publication year
2013
Publication date
Oct 2013
Publisher
Oxford University Press
ISSN
20488505
e-ISSN
20488513
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3170138099
Copyright
© The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: [email protected]. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.