Abstract

IgG4-related disease (IgG4-RD) is associated with the infiltration of IgG4-positive plasma cells into various organs. Nephropathy of IgG4-RD is generally interstitial nephritis and glomerulonephritis is rare. We describe a case of membranous nephropathy (MN) without interstitial nephritis associated with IgG4-RD symptoms including lymphadenopathy and pulmonary and pleural lesions. Treatment with steroids improved these clinical symptoms, but withdrawal of steroids induced the repeated relapse of MN. Finally, flaring of MN was prevented by the combination of steroids and cyclosporine. This is the first report of the successful treatment of MN associated with IgG4-RD by this combination therapy.

Details

Title
Membranous nephropathy with repeated flares in IgG4-related disease
Author
Kanda, Hiroko 1 ; Koya, Junji 2 ; Uozaki, Hiroshi 3 ; Tateishi, Shoko 1 ; Sato, Kojiro 4 ; Hagino, Noboru 5 ; Sawada, Tetsuji 6 ; Yamamoto, Kazuhiko 1 

 Department of Allergy and Rheumatology, University of Tokyo, Tokyo, Japan 
 Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan 
 Department of Pathology, University of Tokyo, Tokyo, Japan 
 Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan 
 Department of Hematology and Rheumatology, Teikyo University Chiba Medical Center, Ichihara, Japan 
 Department of Rheumatology, Tokyo Medical University Hospital, Tokyo, Japan 
Pages
204-207
Publication year
2013
Publication date
Apr 2013
Publisher
Oxford University Press
ISSN
20488505
e-ISSN
20488513
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3170681726
Copyright
© The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. This work is published under http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.