Abstract

Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt.

Details

Title
Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study
Author
Liu, Jiajun 1   VIAFID ORCID Logo  ; Tong, Steven Y C 2 ; Davis, Joshua S 3   VIAFID ORCID Logo  ; Rhodes, Nathaniel J 1   VIAFID ORCID Logo  ; Scheetz, Marc H 1 ; Anagostou, Nick; Andresen, David; Archuleta, Sophia; Bak, Narin; Cass, Alan; Chatfield, Mark; Cheng, Alan; Davies, Jane; Davis, Joshua; Dishon, Yael; Dotel, Ravindra; Ferguson, Patricia; Foo, Hong; Fowler, Vance; Ghosh, Niladri; Gray, Timothy; Guy, Stephen; Holmes, Natasha; Howden, Benjamin; Johnson, Sandra; Kalimuddin, Shirin; Lye, David; McBride, Stephen; McKew, Genevieve; Meagher, Niamh; Nelson, Jane; Matthew O’Sullivan; Paterson, David; Mical, Paul; Price, David; Ralph, Anna; Roberts, Matthew; Robinson, Owen; Rogers, Ben; Runnegar, Naomi; Smith, Simon; Sud, Archana; Tong, Steven; Tramontana, Adrian; Sebastian Van Hal; Walls, Genevieve; Warner, Morgyn; Yahav, Dafna; Young, Barnaby

 Midwestern University Chicago College of Pharmacy, Downers Grove, Illinois, USA; Northwestern Memorial Hospital, Chicago, Illinois, USA; Midwestern University Chicago College of Pharmacy Pharmacometrics Center of Excellence, Downers Grove, Illinois, USA 
 Victorian Infectious Diseases Service, The Royal Melbourne Hospital, and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia; Menzies School of Health Research, Charles Darwin University, Darwin, Australia 
 Menzies School of Health Research, Charles Darwin University, Darwin, Australia 
Publication year
2020
Publication date
Dec 2020
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3170947119
Copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.