Abstract

Objective

There is limited data on abdominal obesity and the influence of genetics on weight change after antiretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study (SHCS).

Methods

Mixed-effects models characterizing BMI and WHR change over time in 1090 SHCS participants initiating ART between 2005 and 2015 were developed and used to quantify the influence of demographics, clinical factors, and genetic background.

Results

Individuals with CD4 nadir <100 cells/µL gained 6.4 times more BMI than individuals with ≥200, and 2.8 times more WHR than individuals with ≥100 (P < .001) during the first 1.5 and 2.5 years after ART initiation, respectively. The risk of being overweight or obese after 1.5 years increased with CD4 nadir <100 cells/µL compared to 100–199 (odds ratio [OR], 2.07; 95% confidence interval [CI], 1.63–2.74) and ≥200 (OR, 1.69; 95% CI, 1.26–2.32), persisting after 10 years of ART. The risk of abdominal obesity after 2.5 years increased with CD4 nadir <100 compared to ≥100 (OR, 1.35; 95% CI, 1.17–1.54 [in men]; OR, 1.36; 95% CI, 1.18–1.57 [in women]), persisting after 10 years of ART. No significant differences were found across antiretroviral drug classes or genetic scores.

Conclusions

The risk of general and abdominal obesity increased with CD4 nadir <100 cells/µL. Based on our results, including the genetic background would not improve obesity predictions in HIV-infected individuals.

Details

Title
Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy
Author
Barceló, Catalina 1 ; Guidi, Monia 2 ; Thorball, Christian W 3 ; Hammer, Christian 4 ; Chaouch, Aziz 5 ; Scherrer, Alexandra U 6 ; Hasse, Barbara 7 ; Cavassini, Matthias 8 ; Furrer, Hansjakob 9 ; Calmy, Alexandra 10 ; Haubitz, Sebastian 11 ; Bernasconi, Enos 12 ; Buclin, Thierry 5 ; Fellay, Jacques 13 ; Tarr, Philip E 14 ; Csajka, Chantal 15 ; Anagnostopoulos, A; Battegay, M; Bernasconi, E; Böni, J; Braun, D L; Bucher, H C; Calmy, A; Cavassini, M; Ciuffi, A; Dollenmaier, G; Egger, M; Elzi, L; Fehr, J; Fellay, J; Furrer, H; Fux, C A; Günthard, H F; Haerry, D; Hasse, B; Hirsch, H H; Hoffmann, M; Hösli, I; Huber, M; Kahlert, C R; Kaiser, L; Keiser, O; Klimkait, T; Kouyos, R D; Kovari, H; Ledergerber, B; Martinetti, G; Martinez de Tejada, B; Marzolini, C; Metzner, K J; Müller, N; Nicca, D; Paioni, P; Pantaleo, G; Perreau, M; Rauch, A; Rudin, C; Scherrer, A U; Schmid, P; Speck, R; Stöckle, M; Tarr, P; Trkola, A; Vernazza, P; Wandeler, G; Weber, R; Yerly, S

1  Center for Research and Innovation in Clinical Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Lausanne, Lausanne, Switzerland 
2  Center for Research and Innovation in Clinical Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Lausanne, Lausanne, Switzerland; Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Switzerland 
3  School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland 
4  Department of Cancer Immunology, Genentech, South San Francisco, CA, USA; Department of Human Genetics, Genentech, South San Francisco, CA, USA 
5  Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Switzerland 
6  Institute of Medical Virology, University of Zurich, Zurich, Switzerland 
7  Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland 
8  Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland 
9  Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland 
10  Division of Infectious Diseases, HIV/AIDS Unit, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland 
11  Department of Infectious Diseases and Hospital Hygiene, Kantonsspital Aarau, Switzerland 
12  Division of Infectious Diseases, Regional Hospital, Lugano, Switzerland 
13  School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland 
14  University Department of Medicine, Infectious Diseases Service, Kantonsspital Baselland, University of Basel, Switzerland 
15  Center for Research and Innovation in Clinical Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Lausanne, Lausanne, Switzerland; School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland 
Publication year
2020
Publication date
Jan 2020
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1093/ofid/ofz464
ProQuest document ID
3171021093
Copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: [email protected]. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.