Abstract
Fourty patients were treated with meropenem-vaborbactam (MEV) for serious Gram-negative bacterial (GNB) infections. Carbapenem-resistant Enterobacteriaceae (CRE) comprised 80.0% of all GNB infections. Clinical success occurred in 70.0% of patients. Mortality and recurrence at 30 days were 7.5% and 12.5%, respectively. One patient experienced a probable rash due to MEV.
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1 Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
2 Department of Pharmacy Services, Detroit Medical Center, Detroit, Michigan, USA
3 College of Pharmacy, University of Houston, Houston, Texas, USA
4 Department of Pharmacy, Inova Fairfax Medical Campus, Falls Church, Virginia, USA
5 College of Pharmacy, University of Florida, Gainesville, Florida, USA
6 College of Pharmacy, University of Tennessee, Knoxville, Tennessee, USA; University of Tennessee Medical Center, Knoxville, Tennessee, USA
7 Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
8 Beaumont Hospital, Royal Oak, Michigan, USA
9 Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA; Department of Pharmacy, Henry Ford Hospital, Detroit, Michigan, USA
10 Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA; Department of Pharmacy Services, Detroit Medical Center, Detroit, Michigan, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Wayne State University, Detroit, Michigan, USA