Research Progress of Tumor-associated Neutrophils in the Occurrence and Development of Lung Cancer

Abstract

肺癌在全球范围内是死亡率最高的恶性肿瘤类型。肿瘤微环境（tumor microenvironment, TME）是导致肺癌进展的关键因素，由肿瘤细胞、信号分子、成纤维细胞及免疫细胞等组成。其中，肿瘤相关中性粒细胞（tumor associated neutrophil, TAN）作为构成TME中免疫细胞的重要组成部分，其功能异常在肿瘤细胞的增殖、侵袭、血管生成和转移等环节发挥着多重作用，并与不良预后紧密相关。然而，TAN在肺癌中的作用机制研究较少。本综述通过阐述TAN的不同分型及其在肺癌发生、发展中的作用机制，旨在为研究肺癌的治疗靶点、开发新的药物提供更多的科学依据。

Lung cancer is the malignant tumor with the highest mortality rate worldwide. The tumor microenvironment (TME) is a key factor in the progression of lung cancer, composed of tumor cells, signaling molecules, fibroblasts, immune cells, etc. Among them, tumor associated neutrophil (TAN), as an important component of immune cells in the TME, plays multiple roles in tumor cell proliferation, invasion, angiogenesis, and metastasis due to its aberrant function, and is closely associated with poor prognosis. However, there are limited researches on the mechanism of TAN in lung cancer. This review aims to provide more scientific basis for studying the therapeutic targets of lung cancer and developing new drugs by elucidating the different subtypes of TAN and their mechanisms of action in the occurrence and development of lung cancer.