Dual Roles of Neutrophil Extracellular Traps in Lung Cancer: Mechanism Exploration and Therapeutic Prospects

Abstract

肺癌是中国居民中发病率和死亡率均较高的恶性肿瘤之一。在肿瘤微环境中，中性粒细胞所分泌的中性粒细胞胞外诱捕网（neutrophil extracellular traps, NETs）在肺癌的形成与进展过程中发挥着至关重要的作用。尽管NETs促进肿瘤发展的确切机制尚未完全阐明，但现有的研究已经揭示了它们在肿瘤生长、侵袭、转移以及癌症相关血栓形成中发挥多重作用。本文将结合近年来的研究，综述NETs在肺癌中的分子生物学机制及研究进展。

Lung cancer is one of the most common and lethal malignancies in China. In the context of the tumor microenvironment, neutrophil extracellular traps (NETs) released by neutrophils exert a profound impact on the occurrence and progression of lung cancer. Although the exact mechanisms by which NETs promote tumor growth have not been fully elucidated, existing research has revealed their multiple roles in tumor growth, invasion, metastasis, and cancer-related thrombosis. This article will review the molecular biology mechanisms and research progress of NETs in lung cancer based on recent studies.