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Abstract
Heightened muscle sympathetic nerve activity (MSNA) contributes to impaired vasodilatory capacity and vascular dysfunction associated with aging and cardiovascular disease. The contribution of elevated MSNA to the vasodilatory response during passive leg movement (PLM) is not fully understood. This study tested the hypothesis that elevated MSNA diminishes the vasodilatory response to PLM in healthy young males (
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1 Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA, Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA
2 Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA, Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, USA
3 Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA, Mayo Clinic School of Health Sciences, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, Minnesota, USA
4 Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA, School of Health and Kinesiology, University of Nebraska Omaha, Omaha, Nebraska, USA
5 Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA, Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA