Abstract

The mechanistic target of rapamycin (mTOR) acts as a negative regulator of autophagy and lysosomal biogenesis. Exercise training has always been known as one of the nondrug strategies to improve insulin sensitivity, glucose metabolism, and overall metabolic health in people with T2DM [16]. [...]this study investigated the interactive effects of HIIT and vitamin D3 injection on cell signaling pathways involved in excessive autophagy, specifically the mTOR–Beclin-1–Fyco-1–CTSD pathway, in the heart tissue of T2DM-induced rats. 2. Parameters included in the calculation included an expected effect size of 0.40, a significance level of 0.05, a statistical power ( 1−β) of 0.80, and five experimental groups.

Details

Title
The Effect of Vitamin D3 Injection Combined With High-Intensity Interval Training on Excessive Autophagy in the Heart Tissue of Type 2 Diabetes–Induced Rats: An Analysis of the mTOR–Beclin-1–Fyco-1–Cathepsin D Pathway
Author
Golpasandi, Hadi 1   VIAFID ORCID Logo  ; Mohammad Rahman Rahimi 1   VIAFID ORCID Logo 

1  Department of Exercise Physiology Faculty of Humanities and Social Sciences University of Kurdistan Sanandaj Iran 
Editor
Victor Garcia
Publication year
2025
Publication date
2025
Publisher
John Wiley & Sons, Inc.
ISSN
17555914
e-ISSN
17555922
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1155/cdr/8817195
ProQuest document ID
3183244307
Copyright
Copyright © 2025 Hadi Golpasandi and Mohammad Rahman Rahimi. Cardiovascular Therapeutics published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (the “License”), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/