Content area

Abstract

The prediction of uterine cancer recurrence is very important for assisting women in reducing the cancer risks and also for the growing field of personalized medicine. The primary aim of this thesis is to investigate the integration of various omics data alongside clinical and therapeutic information to predict survival in uterine cancer. The combination is very important for understanding the risk factors, including clinical aspects, genetics, and the treatment schedule, in order to prescribe the appropriate way to reduce the risk of recurrence, make clinical interactions easier, and enhance personalized patient care. This study utilizes the publicly accessible TCGA dataset, which includes multiple types of omics data, including mRNA, DNA Methylation, and Copy Number Alterations, alongside clinical data such as patient demographics, treatment details, and surgical information. This study involves employing a modern Graph Attention Networks model for generating embeddings, which were subsequently input into an ensemble classifier comprising MLP, SVM, Random Forest, and XGBoost classifiers. The performance of various classifiers and the ensemble model is analyzed to demonstrate the efficiency of each model using metrics like accuracy, AUC score, F-1 score, precision, recall, sensitivity and specificity. This strategy yielded a significant improvement in the accuracy of predicting uterine cancer recurrence.

Details

1010268
Title
Integrative Multi-Omics and Clinical Data Analysis for Predicting Recurrence and Survival in Uterine Cancer
Number of pages
49
Publication year
2025
Degree date
2025
School code
0206
Source
MAI 86/10(E), Masters Abstracts International
ISBN
9798314812983
Committee member
Canavan, Shaun; Kim, Seungbae; Kohut, Adrian
University/institution
University of South Florida
Department
Computer Science and Engineering
University location
United States -- Florida
Degree
M.S.C.S.
Source type
Dissertation or Thesis
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
31932230
ProQuest document ID
3196743133
Document URL
https://www.proquest.com/dissertations-theses/integrative-multi-omics-clinical-data-analysis/docview/3196743133/se-2?accountid=208611
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Database
ProQuest One Academic