Various Aspects of Solid Dispersion Technology: A Review

Abstract

Because of solubility issues, improving the bioavailability of drugs administered orally in solid medicament continue to be an obstacle for scientists dealing with the formulation design. A solid dosage form's absorption of somewhat insoluble medications may be slowed down by their rate of disintegration. Therefore, scientists have a problem in improving the solubility aspects of the poorly soluble drugs utilizing solid dispersion approach. Solid dispersion methods have generated a lot of attention because they can speed up the dissolution aspects of the highly lipophilic medications and comparatively increase the bioavailability by lowering particle size of drug, enhancing wettability and creating amorphous particles. A class of solid products with at least two separate ingredients, often a hydrophobic medication or a hydrophilic inert carrier, are referred to as solid dispersions. Standard formulations like tablets or capsules can be replaced with solid dispersion made utilizing a number of processes, and it offers numerous benefits over them. This review summarizes and aims to give an insight about BCS classification, types of solid dispersion, their mechanism for solubility enhancement, carriers employed, methods of solid dispersion preparation, advantages, limitations, characterization and research work related to solid dispersions.