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18F-fluorodeoxyglucose (18F-FDG) is a radiopharmaceutical that exhibits glucose-like kinetics and is used in positron emission tomography (PET). 18F-FDG is used for cancer diagnosis in clinical practice. However, 18F-FDG uptake is also observed in normal organs, such as the brain, liver, and heart, with high glucose consumption. Moreover, 18F-FDG uptake is also observed in muscles, where its accumulation and radioactivity reflect muscle activity. Dystonia is characterized by excessive muscle movement. Recently, 18F-FDG and technetium-99m-methoxyisobutyl isocyanide ([99mTc]MIBI) have been used for the diagnosis and botulinum toxin therapy evaluation of dystonia.

This review aimed to summarize the utility of 18F-FDG-PET for the evaluation of muscle activity and diagnosis of muscle diseases such as dystonia, polymyositis, dermatomyositis, and polymyalgia rheumatica.

Details

1009240
Subject
Glucose;
Tomography;
Metabolism;
Shoulder;
Muscle function;
Clinical medicine;
Scintigraphy;
Disease;
Nuclear medicine;
Dystonia;
Magnetic resonance imaging
Location
United States--US
Identifier / keyword
18f-fdg; dermatomyositis; dystonia; muscle; pet; polymyositis
Title
Muscle Function, Muscle Disease, and Positron Emission Tomography-Computed Tomography: A Narrative Review
Author
Yamamoto Shinji 1 ; Okada Yukinori 2 

1  Department of Radiological Technology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Tokyo, JPN 
2  Department of Radiology, Tokyo Medical University Hospital, Tokyo, JPN 
Publication title
Cureus; Palo Alto
Volume
17
Issue
2
Publication year
2025
Publication date
2025
Publisher
Springer Nature B.V.
Place of publication
Palo Alto
Country of publication
Netherlands
University/institution
U.S. National Institutes of Health/National Library of Medicine
Publication subject
Medical Sciences
e-ISSN
21688184
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
Publication history
 
 
Online publication date
2025-02-28
Milestone dates
2025-02-28 (Accepted)
Publication history
 
 
   First posting date
28 Feb 2025
DOI
https://doi.org/10.7759/cureus.79857
ProQuest document ID
3204272222
Document URL
https://www.proquest.com/scholarly-journals/muscle-function-disease-positron-emission/docview/3204272222/se-2?accountid=208611
Full text outside of ProQuest
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955744/
Copyright
Copyright © 2025, Yamamoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2025-12-04
Database
ProQuest One Academic