Does Mammographic Density Predict Pathological Complete Response in Patients with Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy?

Abstract

[LANGUAGE= "English"] Objectives: We aimed to investigate the relationship between mammographic density (MD) category and pathologi?cal complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy. Methods: The study population consisted of 98 breast cancer patients. At the time of diagnosis, MD was categorised according to BIRADS 5th Edition. pCR was defined as the absence of residual tumour cells in the breast and axilla after completion of neoadjuvant chemotherapy (NACT). Results: Patients with less dense breast density (MD category A+B) were significantly older than patients with more dense breast density (MD category C+D) (p=0.001). When patients were divided according to BIRADS classification (A/B and C/D), there was no statistical difference in performing pCR between patients with high MD and patients with low MD (p=0.684 ;%95 GA 0.67-0.69). Conclusion: In previous studies, conflicting results were obtained in the relationship between MD value and treatment response. In our study, MD was not an independent predictor of response to breast cancer NACT.

Alternate abstract:

Objectives: We aimed to investigate the relationship between mammographic density (MD) category and pathologi?cal complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy. Methods: The study population consisted of 98 breast cancer patients. At the time of diagnosis, MD was categorised according to BIRADS 5th Edition. pCR was defined as the absence of residual tumour cells in the breast and axilla after completion of neoadjuvant chemotherapy (NACT). Results: Patients with less dense breast density (MD category A+B) were significantly older than patients with more dense breast density (MD category C+D) (p=0.001). When patients were divided according to BIRADS classification (A/B and C/D), there was no statistical difference in performing pCR between patients with high MD and patients with low MD (p=0.684 ;%95 GA 0.67-0.69). Conclusion: In previous studies, conflicting results were obtained in the relationship between MD value and treatment response. In our study, MD was not an independent predictor of response to breast cancer NACT.