Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation in the Development and Immune Escape of Non-small Cell Lung Cancer

Abstract

非小细胞肺癌（non-small cell lung cancer, NSCLC）作为全球癌症死亡的主要原因，尽管免疫检查点抑制剂的治疗取得进展，但耐药性仍是一个重大的临床挑战。棕榈酰化是一种关键的蛋白质翻译后修饰（post- translational modifications, PTM），主要由含锌指DHHC结构型（zinc finger DHHC-type, ZDHHC）的棕榈酰基转移酶催化，近年研究表明其在NSCLC中具有重要意义。本综述旨在阐明ZDHHC介导的蛋白质棕榈酰化在NSCLC发生发展和免疫逃逸中的作用机制及临床应用前景。

Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape.