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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Coherent anti-Stokes Raman scattering (CARS) is a powerful nonlinear spectroscopic technique widely used in biological imaging, chemical analysis, and combustion and flame diagnostics. The adoption of pulse shapers in CARS has emerged as a useful approach, offering precise control of optical waveforms. By tailoring the phase, amplitude, and polarization of laser pulses, the pulse shaping approach enables selective excitation, spectral resolution improvement, and non-resonant background suppression in CARS. This paper presents a comprehensive review of applying pulse shaping techniques in CARS spectroscopy for biophotonics. There are two different pulse shaping strategies: passive pulse shaping and active pulse shaping. Two passive pulse shaping techniques, hybrid CARS and spectral focusing CARS, are reviewed. Active pulse shaping using a programmable pulse shaper such as spatial light modulator (SLM) is discussed for CARS spectroscopy. Combining active pulse shaping and passive shaping, optimizing CARS with acousto-optic programmable dispersive filters (AOPDFs) is discussed and illustrated with experimental examples conducted in the authors’ laboratory. These results underscore pulse shapers in advancing CARS technology, enabling improved sensitivity, specificity, and broader applications across diverse scientific fields.

Details

Title
Coherent Vibrational Anti-Stokes Raman Spectroscopy Assisted by Pulse Shaping
Author
Wang, Kai 1   VIAFID ORCID Logo  ; Florence, James T 1 ; Xia, Hua 2   VIAFID ORCID Logo  ; Han Zehua 1 ; Shen Yujie 3 ; Wang Jizhou 1   VIAFID ORCID Logo  ; Wang, Xi 1 ; Sokolov, Alexei V 1   VIAFID ORCID Logo 

 Department of Physics and Astronomy, Institute for Quantum Science and Engineering, Texas A&M University, College Station, TX 77843, USA; [email protected] (J.T.F.); [email protected] (Z.H.); [email protected] (J.W.); [email protected] (X.W.) 
 Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China; [email protected] 
 Laboratory of Neurotechnology and Biophysics, Rockefeller University, New York, NY 10065, USA; [email protected] 
First page
2243
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3212086062
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.