Abstract

Backgrounds

Alcoholic liver disease (ALD), a consequence of excessive alcohol consumption, is characterized by high incidence and mortality rates. Presently, there are no effective pharmacological interventions available for the treatment of ALD. Baicalin (BA), a natural flavonoid derived from the root of Scutellaria baicalensis, has exhibited notable hepatoprotective effects. Nevertheless, the mechanisms through which BA influences the interaction between suppressor of cytokine signaling 1 (SOCS1) and macrophages during hepatic immune development remain insufficiently understood.

Materials and methods

This study seeks to examine the regulatory effects of BA on ALD and to elucidate the relationship between SOCS1 and macrophage differentiation. Our experimental methodology involves the novel application of zebrafish as an in vivo model for ALD. To further investigate the underlying mechanisms, we employed gene knockout and overexpression techniques.

Results

The study demonstrates that BA substantially alleviates ALD in both in vivo and in vitro settings by upregulating SOCS1 expression in macrophages. Furthermore, we elucidated the association between SOCS1 and macrophage reprogramming. Specifically, SOCS1 knockdown led to the downregulation of CD86, CD80, and iNOS expression, whereas SOCS1 overexpression enhanced the expression of CD206, CD163, IL-4, and IL-10.

Conclusion

In conclusion, our findings suggest that BA attenuates ALD via the modulation of SOCS1-mediated macrophage reprogramming.

Details

Title
Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages
Author
Huang, Sha; Wang, Yuhua; Wen, Jinjie; Ji, Wenjuan; Zeng, Qiuxiang; Deng, Kaili; Li, Min; Kuang, Shanshan; Zhang, Wen; Chan, Mo; Zhou, Chuying; Lv, Zhiping; Huang, Shaohui
Pages
1-15
Section
Research
Publication year
2025
Publication date
2025
Publisher
BioMed Central
ISSN
17498546
e-ISSN
1749-8546
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3216564053
Copyright
© 2025. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.