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Congenital Heart Diseases (CHDs) are a heterogeneous group of structural abnormalities affecting the heart and major arteries, which are present in at least 1% of births worldwide. Studies have linked CHD to both genetic and environmental factors. In this regard, it has been demonstrated that changes in the epigenetic pattern impact the expression of key genes involved in proper cardiac development. Therefore, it is suggested that aberrant epigenetic mechanisms may contribute to the development of these pathologies. Here, we review and summarize the main epigenetic mechanisms involved in CHD. Moreover, cardiac development and the importance of the environment and CHD are also addressed.
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Subject
Identifier / keyword
Title
Congenital Heart Diseases: Recent Insights into Epigenetic Mechanisms
Author
Rodríguez-Pérez, José Manuel 1
; Ortega-Zhindón, Diego B 2
; Villamil-Castañeda, Clara 3
; Lara-Ortiz, Javier Santiago 1
; Borgonio-Cuadra Verónica Marusa 4 ; Cervantes-Salazar, Jorge L 5
; Calderón-Colmenero, Juan 6 ; Escalante-Ruiz Zeomara Nathali 7
; Retama-Méndez Eduardo 7
; Hernández-García, Yessica C 5 ; Pérez-Hernández Nonanzit 1
1 Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (J.M.R.-P.); [email protected] (C.V.-C.); [email protected] (J.S.L.-O.); [email protected] (Z.N.E.-R.); [email protected] (E.R.-M.)
2 Department of Pediatric Cardiac Surgery and Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (D.B.O.-Z.); [email protected] (J.L.C.-S.); [email protected] (Y.C.H.-G.), Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
3 Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (J.M.R.-P.); [email protected] (C.V.-C.); [email protected] (J.S.L.-O.); [email protected] (Z.N.E.-R.); [email protected] (E.R.-M.), Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
4 Laboratory of Genomic Medicine, Department of Genetics, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico; [email protected]
5 Department of Pediatric Cardiac Surgery and Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (D.B.O.-Z.); [email protected] (J.L.C.-S.); [email protected] (Y.C.H.-G.)
6 Department of Pediatric Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected]
7 Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (J.M.R.-P.); [email protected] (C.V.-C.); [email protected] (J.S.L.-O.); [email protected] (Z.N.E.-R.); [email protected] (E.R.-M.), Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Tabasco, Mexico
; Ortega-Zhindón, Diego B 2
; Villamil-Castañeda, Clara 3
; Lara-Ortiz, Javier Santiago 1
; Borgonio-Cuadra Verónica Marusa 4 ; Cervantes-Salazar, Jorge L 5
; Calderón-Colmenero, Juan 6 ; Escalante-Ruiz Zeomara Nathali 7
; Retama-Méndez Eduardo 7
; Hernández-García, Yessica C 5 ; Pérez-Hernández Nonanzit 1
1 Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (J.M.R.-P.); [email protected] (C.V.-C.); [email protected] (J.S.L.-O.); [email protected] (Z.N.E.-R.); [email protected] (E.R.-M.)
2 Department of Pediatric Cardiac Surgery and Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (D.B.O.-Z.); [email protected] (J.L.C.-S.); [email protected] (Y.C.H.-G.), Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
3 Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (J.M.R.-P.); [email protected] (C.V.-C.); [email protected] (J.S.L.-O.); [email protected] (Z.N.E.-R.); [email protected] (E.R.-M.), Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
4 Laboratory of Genomic Medicine, Department of Genetics, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico; [email protected]
5 Department of Pediatric Cardiac Surgery and Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (D.B.O.-Z.); [email protected] (J.L.C.-S.); [email protected] (Y.C.H.-G.)
6 Department of Pediatric Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected]
7 Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico; [email protected] (J.M.R.-P.); [email protected] (C.V.-C.); [email protected] (J.S.L.-O.); [email protected] (Z.N.E.-R.); [email protected] (E.R.-M.), Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Tabasco, Mexico
Cells; Basel
Volume
14
Issue
11
First page
820
Publication year
2025
Publication date
2025
Place of publication
Basel
Country of publication
Switzerland
Publication subject
e-ISSN
20734409
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
Publication history
Online publication date
2025-05-31
Milestone dates
2025-04-20 (Received); 2025-05-29 (Accepted)
Publication history
First posting date
31 May 2025
ProQuest document ID
3217719616
Document URL
https://www.proquest.com/scholarly-journals/congenital-heart-diseases-recent-insights-into/docview/3217719616/se-2?accountid=208611
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2025-07-18
Database
ProQuest One Academic