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Purpose - The purpose of the study is to examine the relationship between resource dependence and environmental uncertainty. The study investigates whether there is a relationship between resource dependency and environmental uncertainty in organizations operating in various sectors. Methodology - The sample for the research consists of organizations listed in the ISO 500 list that operate in the TR63 region (N=25). IBM SPSS Statistics 21 was used for data analysis, and non-parametric analysis methods were applied. Findings - The results of the analysis indicate that there is no relationship between resource dependency and environmental uncertainty. It can be concluded that the organizations involved in the study do not use their resource dependency strategies to manage the uncertainty arising from their environment. Conclusions - Although the analysis results show no direct relationship between resource dependency and environmental uncertainty, it can be stated that organizations use resource dependency strategies for purposes such as achieving cost advantages, keeping up with innovations, and enhancing productivity and efficiency.