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Abstract
AL002 Sex differences in RAMP1/RAMP2 expression in the human middle meningeal artery match functional response to CGRP T. de Vries, D. Schutter1, R. Dammers2, A. Vincent2, A. H. J. Danser1, A. Maassen van den Brink1 1Erasmus MC University Medical Center, Internal Medicine, Division of Pharmacology and Vascular Medicine, Rotterdam, Netherlands; 2Erasmus MC University Medical Center, Neurosurgery, Rotterdam, Netherlands Correspondence: T. de Vries The Journal of Headache and Pain 2025, 26(Suppl 2):AL002 Objective: CGRP induces vasodilation after binding to the CGRP receptor (CLR-RAMP1), but can activate the adrenomedullin receptor (CLR-RAMP2) as well. Maximum response to CGRP (redrawn after de Vries et al. 20241) and relative expression of RAMP1 and RAMP2 2 with age in men and women separately AL003 Enhancing migraine prediction with behavioral dynamics and transformer models M. Ouellet1,2, C. Siebra1,3, K. Wac1 1University of Geneva, Quality of Life Technologies Lab, Carouge, Switzerland; 2Hasso Plattner Institute, Digital Health Cluster, Postdam, Germany; 3Federal University of Paraiba, Informatics Center, João Pessoa, Brazil Correspondence: M. Ouellet The Journal of Headache and Pain 2025, 26(Suppl 2):AL003 Objective: Our study explores the feasibility of using behavioral features and transformer models to improve forecasting next-day migraine attacks, aiming to enhance the quality of life for migraine sufferers. The 3-day window prior shows the highest magnitude of feature importance, and the benefit of sequence models in understanding effects over time given the change in direction of some feature effects as early as 1 day prior. Methods: We recorded somatosensory evoked potentials (SSEPs) to collect electrophysiological data from low- and high-frequency signal"s bands in 177 individuals, including 91 individuals with migraine during their interictal period (MO) and 86 healthy subjects (HS).