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Abstract

Background: Blood transfusion is a therapeutic procedure characterized by the use of blood components for the treatment of certain pathologies. When applied properly, it is highly successful; however, it also has risks, such as transfusion reactions. Objective: This study aimed to evaluate the effects of the clinical simulation of transfusion reactions on the knowledge gain of nursing students. Methods: Two groups were compared: the intervention group, which used the educational intervention: “clinical simulation of transfusion reactions in adults”, and the control group, which did not use the strategy. The study was conducted at a Higher Education Institution from August 2022 to June 2023, with nursing students in the fifth semester. An instrument on the knowledge of transfusion reactions was applied before and seven days after the intervention. Data were analyzed descriptively and inferentially using the Mann–Whitney U and Wilcoxon tests. For both, p < 0.05 was accepted. Results: The Wilcoxon test revealed a statistically significant difference in pre- and post-test scores within the intervention group (p-value: 0.003), with a large effect size (Cohen’s d = 1.14). The average score in the pre-test was 16.47 and increased to 18.93 in the post-test (p = 0.002), while in the control group there was a drop from 14.53 to 12.07 (p = 0.053). In terms of overall scores, the intervention group went from an average of 8.10 to 9.67 (p = 0.001), while the control group went from 8.13 to 8.66 (p = 0.053). The reduction in errors was significant in topics such as hand hygiene (from 56.7% to 23.3%) and the maximum exposure time of the blood component at room temperature (from 66.7% to 20%). The data showed that the clinical simulation intervention had a significant positive effect on the acquisition of theoretical knowledge about transfusion reactions. Conclusions: Through the use of simulation as a teaching strategy, students gained greater knowledge.

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Title
The Effects of the Clinical Simulation of Transfusion Reactions on Nursing Students’ Knowledge Gain: A Pragmatic Clinical Trial
Author
Rodrigues Ana Beatriz Frota Lima 1   VIAFID ORCID Logo  ; Ozorio Dutra Samia Valéria 2   VIAFID ORCID Logo  ; dos Santos Maria Ivaneide Teixeira 3   VIAFID ORCID Logo  ; Araujo, Lucas Ribeiro 1   VIAFID ORCID Logo  ; Ferreira Annie Leticia de Holanda 1 ; Feitosa, Jacinto Arthur 1 ; da Conceição Brenda Sousa 1 ; Lima, Gleiciane Kélen 4   VIAFID ORCID Logo  ; Mendes, Igor Cordeiro 4   VIAFID ORCID Logo  ; Negri, Elaine Cristina 5   VIAFID ORCID Logo  ; de Fátima Fernandes Maria Neyrian 1   VIAFID ORCID Logo  ; Fonseca Luciana Mara Monti 6   VIAFID ORCID Logo  ; Soares Francisco Mayron Morais 1   VIAFID ORCID Logo 

 Department of Nursing, Federal University of Maranhão, Imperatriz 65915-240, MA, Brazil; [email protected] (A.B.F.L.R.); [email protected] (L.R.A.); [email protected] (A.L.d.H.F.); [email protected] (A.F.J.); [email protected] (B.S.d.C.); [email protected] (M.N.d.F.F.) 
 School of Nursing and Dental Hygiene, University of Hawaii at Manoa, Honolulu, HI 96822, USA; [email protected] 
 INTA Uninta University Center, Itapipoca 62600-000, CE, Brazil; [email protected] 
 Department of Nursing, State University of Ceará, Fortaleza 60714-903, CE, Brazil; [email protected] (G.K.L.); [email protected] (I.C.M.) 
 Department of Nursing, University of West Paulista, Presidente Prudente 19050-920, SP, Brazil; [email protected] 
 Escola de Enfermagem de Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-902, SP, Brazil; [email protected] 
Publication title
Volume
15
Issue
6
First page
693
Number of pages
14
Publication year
2025
Publication date
2025
Publisher
MDPI AG
Place of publication
Basel
Country of publication
Switzerland
Publication subject
e-ISSN
22277102
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
Publication history
 
 
Online publication date
2025-06-03
Milestone dates
2025-02-22 (Received); 2025-05-29 (Accepted)
Publication history
 
 
   First posting date
03 Jun 2025
ProQuest document ID
3223899857
Document URL
https://www.proquest.com/scholarly-journals/effects-clinical-simulation-transfusion-reactions/docview/3223899857/se-2?accountid=208611
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2025-06-25
Database
ProQuest One Academic